Recombinant Human DDB1, His-tagged DDB1-11877H

Recombinant Human DDB1, His-tagged

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Recombinant Human DDB1, His-tagged

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Cat.No. : DDB1-11877H
Product Overview : Recombinant Human DDB1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description : The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
Source : E.coli
Species : Human
Tag : His
Protein length : N-term-400a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : DDB1 damage-specific DNA binding protein 1, 127kDa [ Homo sapiens ]
Official Symbol : DDB1
Synonyms : DDB1; damage-specific DNA binding protein 1, 127kDa; damage specific DNA binding protein 1 (127kD); DNA damage-binding protein 1; XPE; XAP-1; UV-DDB 1; DDB p127 subunit; XPE-binding factor; HBV X-associated protein 1; DNA damage-binding protein a; UV-damaged DNA-binding factor; UV-damaged DNA-binding protein 1; damage-specific DNA-binding protein 1; xeroderma pigmentosum group E-complementing protein; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1;
Gene ID : 1642
mRNA Refseq : NM_001923
Protein Refseq : NP_001914
MIM : 600045
UniProt ID : Q16531
Chromosome Location : 11q12-q13
Pathway : Cul4-DDB1-CSA complex, organism-specific biosystem; Cul4-DDB1-DDB2 complex, organism-specific biosystem; DNA Repair, organism-specific biosystem; Dual incision reaction in GG-NER, organism-specific biosystem; Formation of incision complex in GG-NER, organism-specific biosystem; Global Genomic NER (GG-NER), organism-specific biosystem; Nucleotide Excision Repair, organism-specific biosystem;
Function : DNA binding; damaged DNA binding; protein binding;

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