"DOCK4" Related Products

Recombinant Human DOCK4, GST-tagged

Cat.No.: DOCK4-12119H
Product Overview: Recombinant Human DOCK4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized.
Source: E.coli
Species: Human
Tag: GST
Protein length: C-term-310a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: DOCK4 dedicator of cytokinesis 4 [ Homo sapiens ]
Official Symbol: DOCK4
Synonyms: DOCK4; dedicator of cytokinesis 4; dedicator of cytokinesis protein 4; FLJ34238; KIAA0716; MGC134911; MGC134912;
Gene ID: 9732
mRNA Refseq: NM_014705
Protein Refseq: NP_055520
MIM: 607679
UniProt ID: Q8N1I0
Chromosome Location: 7q31.1
Pathway: Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function: GTP binding; GTPase binding; PDZ domain binding; Rac GTPase activator activity; Rac GTPase binding; SH3 domain binding; guanyl-nucleotide exchange factor activity; protein binding; receptor tyrosine kinase binding;

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