Recombinant Human ECEL1, GST-tagged

• Cat.No.: ECEL1-12266H
• Product Overview: Recombinant Human ECEL1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a member of the M13 family of endopeptidases. In general, M13 family members are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. This gene is expressed specifically in the central nervous system and its protein localizes predominately to the endoplasmic reticulum or, in trace amounts, to the cell surface. Disruption of this gene in mouse embryonic stem cells results in neonatal lethality due to respiratory failure shortly after birth. Based on the specific expression of this gene and the phenotype of the gene deficiency in mouse embryos, it is suggested that this protein plays a critical role in neural regulation of the respiratory system. This gene has multiple pseudogenes.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 425-775a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ECEL1 endothelin converting enzyme-like 1 [ Homo sapiens ]
• Official Symbol: ECEL1
• Synonyms: endothelin converting enzyme-like 1; 3147; Ensembl:ENSG00000171551; endothelin-converting enzyme-like 1;X converting enzyme;damage induced neuronal endopeptidase; XCE; DINE; ECEX
• Gene ID: 9427
• mRNA Refseq: NM_004826.2
• Protein Refseq: NP_004817.2
• MIM: 605896
• UniProt ID: O95672
• Chromosome Location: 2q37.1
• Function: metal ion binding; metalloendopeptidase activity; metallopeptidase activity