"EDN3" Related Products

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Recombinant Human EDN3, GST-tagged

Cat.No.: EDN3-12284H
Product Overview: Recombinant Human EDN3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
Source: E.coli
Species: Human
Tag: GST
Protein length: 1-238a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: EDN3 endothelin 3 [ Homo sapiens ]
Official Symbol: EDN3
Synonyms: EDN3; endothelin 3; endothelin-3; ET3; preproendothelin-3; ET-3; WS4B; HSCR4; PPET3; MGC15067; MGC61498;
Gene ID: 1908
mRNA Refseq: NM_000114
Protein Refseq: NP_000105
MIM: 131242
UniProt ID: P14138
Chromosome Location: 20q13.2-q13.3
Pathway: Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Endothelins, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
Function: endothelin B receptor binding; hormone activity; receptor binding;

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