Recombinant Human ELAC2, GST-tagged

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Recombinant Human ELAC2, GST-tagged

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Cat.No. : ELAC2-12395H
Product Overview : Recombinant Human ELAC2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description : The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3 trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : E.coli
Species : Human
Tag : GST
Protein length : 86-385a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : ELAC2 elaC homolog 2 (E. coli) [ Homo sapiens ]
Official Symbol : ELAC2
Synonyms : ELAC2; elaC homolog 2 (E. coli); elaC (E. coli) homolog 2; zinc phosphodiesterase ELAC protein 2; FLJ10530; HPC2; tRNase Z (long form); RNase Z 2; tRNase Z 2; ribonuclease Z 2; tRNA 3 endonuclease 2; elaC homolog protein 2; heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2; ELC2; FLJ36693; FLJ42848;
Gene ID : 60528
mRNA Refseq : NM_001165962
Protein Refseq : NP_001159434
MIM : 605367
UniProt ID : Q9BQ52
Chromosome Location : 17p11.2
Pathway : RNA transport, organism-specific biosystem; RNA transport, conserved biosystem;
Function : endonuclease activity; hydrolase activity; metal ion binding;

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