Recombinant Human FAK, His-tagged

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Recombinant Human FAK, His-tagged

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Cat.No. : FAK-12647H
Product Overview : Recombinant Human FAK protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description : This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
Source : E.coli
Species : Human
Tag : His
Protein length : C-term-298a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : PTK2 PTK2 protein tyrosine kinase 2 [ Homo sapiens ]
Official Symbol : PTK2
Synonyms : PTK2; PTK2 protein tyrosine kinase 2; focal adhesion kinase 1; FADK; FAK; FAK1; PPP1R71; protein phosphatase 1; regulatory subunit 71; FADK 1; FAK-related non-kinase polypeptide; focal adhesion kinase-related nonkinase; protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; FRNK; p125FAK; pp125FAK;
Gene ID : 5747
mRNA Refseq : NM_001199649
Protein Refseq : NP_001186578
MIM : 600758
UniProt ID : Q05397
Chromosome Location : 8q24.3
Pathway : Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Axon guidance, organism-specific biosystem;
Function : ATP binding; JUN kinase binding; SH2 domain binding; binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein tyrosine kinase activity; signal transducer
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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