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Recombinant Human FBXO22, GST-tagged

Cat.No.: FBXO22-12790H
Product Overview: Recombinant Human FBXO22 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants.
Source: E.coli
Species: Human
Tag: GST
Protein length: 104-403a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: FBXO22 F-box protein 22 [ Homo sapiens ]
Official Symbol: FBXO22
Synonyms: FBXO22; F-box protein 22; F box only protein 22; F-box only protein 22; FBX22; FIST domain containing 1; FISTC1; F-box protein FBX22p44; FLJ13986; MGC31799;
Gene ID: 26263
mRNA Refseq: NM_012170
Protein Refseq: NP_036302
MIM: 609096
UniProt ID: Q8NEZ5
Chromosome Location: 15q23
Function: ubiquitin-protein ligase activity;

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