Recombinant Human GHR protein

• Cat.No.: GHR-39H
• Product Overview: Recombinant Human GHR was expressed in E. coli.

Specification

• Description: GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.
• Source: E. coli
• Species: Human
• Form: GHBP was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3.
• Molecular Mass: 28107.01 Dalton
• AA Sequence: AFSGSEATAAILSRAPWSLQSVNPG LKTNS SKEPKFTKCRSPERETFSCHWTDEV HHGTKNLGPIQLFYTRRNTQEWTQE WKECPDYVSA GENSCYFNSSFTSIWIPYCIKLTSN GGTVD
  EKCFSVDEIVQPDPPIALNWTLLNV SLTGI HADIQVRWEAPRNADIQKGWMVLEY ELQYKEVNETKWKMMDPILTTSVPV YSLKVDKEYE VRVRSKQRNSGNYGEFSEVLYVTLP QMSQF
  TCEEDFYF.
• Purity: Greater than 98.0% as determined by:
  (a) Analysis by SEC-HPLC.
  (b) Analysis by SDS-PAGE.
• Storage: Lyophilized Growth Hormone Binding Protein although stable at room temperature for 3 weeks, should be stored desiccated below -18 centigrade. Upon reconstitution GHBP should be stored at 4 centigrade between 2-7 days and for future use below -18 centigrade.
  For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  Please prevent freeze-thaw cycles.
• Reconstitution: It is recommended to reconstitute the lyophilized Growth Hormone Binding Protein in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Gene Information

• Gene Name: GHR growth hormone receptor [ Homo sapiens ]
• Official Symbol: GHR
• Synonyms: GHR; growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein; GHBP
• Gene ID: 2690
• mRNA Refseq: NM_000163
• Protein Refseq: NP_000154
• MIM: 600946
• UniProt ID: P10912
• Chromosome Location: 5p14-p12
• Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem; Growth hormone receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem
• Function: SH2 domain binding; growth factor binding; growth hormone receptor activity; peptide hormone binding; proline-rich region binding; protein binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; receptor activity