Recombinant Human GABRA6, His-tagged

• Cat.No.: GABRA6-13096H
• Product Overview: Recombinant Human GABRA6 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 329-424a.a.
• Description: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 [ Homo sapiens ]
• Official Symbol: GABRA6
• Synonyms: GABRA6; gamma-aminobutyric acid (GABA) A receptor, alpha 6; gamma-aminobutyric acid receptor subunit alpha-6; GABA(A) receptor; alpha 6; GABA(A) receptor, alpha 6; GABA subunit A receptor alpha 6; GABA(A) receptor subunit alpha-6; MGC116903; MGC116904
• Gene ID: 2559
• mRNA Refseq: NM_000811
• Protein Refseq: NP_000802
• MIM: 137143
• UniProt ID: Q16445
• Chromosome Location: 5q34
• Pathway: GABA A receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Ion channel transport, organism-specific biosystem; Ligand-gated ion channel transport, organism-specific biosystem; Morphine addiction, organism-specific biosystem
• Function: GABA-A receptor activity; GABA-gated chloride ion channel activity; benzodiazepine receptor activity; chloride channel activity; drug binding; inhibitory extracellular ligand-gated ion channel activity; ion channel activity; receptor activity