Recombinant Human GNAO1, GST-tagged
Cat.No. : | GNAO1-13349H |
Product Overview : | Recombinant Human GNAO1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-302a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O [ Homo sapiens ] |
Official Symbol : | GNAO1 |
Synonyms : | GNAO1; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide-binding protein G(o) subunit alpha; G ALPHA o; guanine nucleotide binding protein, alpha activating polypeptide O; GNAO; G-ALPHA-o; DKFZp686O0962; |
Gene ID : | 2775 |
mRNA Refseq : | NM_020988 |
Protein Refseq : | NP_066268 |
MIM : | 139311 |
UniProt ID : | P09471 |
Chromosome Location : | 16q13 |
Pathway : | Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cholinergic synapse, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; G Protein Signaling Pathways, organism-specific biosystem; |
Function : | G-protein beta/gamma-subunit complex binding; G-protein coupled serotonin receptor binding; GTP binding; GTPase activity; guanyl nucleotide binding; metal ion binding; mu-type opioid receptor binding; nucleotide binding; phosphatidylinositol phospholipase |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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