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Recombinant Human GNG5, GST-tagged

Cat.No. : GNG5-13365H
Product Overview : Recombinant Human GNG5 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : This gene encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-68a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : GNG5 guanine nucleotide binding protein (G protein), gamma 5 [ Homo sapiens ]
Official Symbol : GNG5
Synonyms : GNG5; guanine nucleotide binding protein (G protein), gamma 5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; FLJ92393;
Gene ID : 2787
mRNA Refseq : NM_005274
Protein Refseq : NP_005265
MIM : 600874
UniProt ID : P63218
Chromosome Location : 1p22
Pathway : ADP signalling through P2Y purinoceptor 1, organism-specific biosystem; ADP signalling through P2Y purinoceptor 12, organism-specific biosystem; Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem; Aquaporin-mediated transport, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem;
Function : GTPase activity; signal transducer activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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