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Recombinant Human HDAC3, GST-tagged

Cat.No.: HDAC3-13707H
Product Overview: Recombinant Human HDAC3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Source: E.coli
Species: Human
Tag: GST
Protein length: 187-395a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: HDAC3 histone deacetylase 3 [ Homo sapiens ]
Official Symbol: HDAC3
Synonyms: HDAC3; histone deacetylase 3; HD3; RPD3; RPD3 2; SMAP45; RPD3-2;
Gene ID: 8841
mRNA Refseq: NM_003883
Protein Refseq: NP_003874
MIM: 605166
UniProt ID: O15379
Chromosome Location: 5q31.1-q31.2
Pathway: BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Cell cycle, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem;
Function: DNA binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); chromatin binding; enzyme binding; histone deacetylase ac

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