"HIP1" Related Products

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Recombinant Human HIP1, GST-tagged

Cat.No.: HIP1-13782H
Product Overview: Recombinant Human HIP1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene.
Source: E.coli
Species: Human
Tag: GST
Protein length: 435-764a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: HIP1 huntingtin interacting protein 1 [ Homo sapiens ]
Official Symbol: HIP1
Synonyms: HIP1; huntingtin interacting protein 1; huntingtin-interacting protein 1; ILWEQ; HIP-I; huntingtin-interacting protein I; MGC126506;
Gene ID: 3092
mRNA Refseq: NM_001243198
Protein Refseq: NP_001230127
MIM: 601767
UniProt ID: O00291
Chromosome Location: 7q11.23
Pathway: Coregulation of Androgen receptor activity, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem;
Function: actin binding; clathrin binding; phosphatidylinositol binding; protein binding; structural constituent of cytoskeleton;

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