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Recombinant Human HMGB2, GST-tagged

Cat.No.: HMGB2-13842H
Product Overview: Recombinant Human HMGB2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
Source: E.coli
Species: Human
Tag: GST
Protein length: 1-195a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: HMGB2 high mobility group box 2 [ Homo sapiens ]
Official Symbol: HMGB2
Synonyms: HMGB2; high mobility group box 2; high mobility group (nonhistone chromosomal) protein 2 , high mobility group box 2 , HMG2; high mobility group protein B2; HMG-2; high-mobility group box 2; high mobility group protein 2; high-mobility group (nonhistone chromosomal) protein 2; HMG2;
Gene ID: 3148
mRNA Refseq: NM_001130688
Protein Refseq: NP_001124160
MIM: 163906
UniProt ID: P26583
Chromosome Location: 4q31
Pathway: Activation of DNA fragmentation factor, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis induced DNA fragmentation, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem;
Function: DNA binding; DNA binding, bending; RAGE receptor binding; chemoattractant activity; damaged DNA binding; double-stranded DNA binding; protein binding; protein domain specific binding; sequence-specific DNA binding transcription factor activity; single-str

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