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Recombinant Human HPD, GST-tagged

Cat.No.: HPD-13920H
Product Overview: Recombinant Human HPD protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene.
Source: E.coli
Species: Human
Tag: GST
Protein length: 1-393a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: HPD 4-hydroxyphenylpyruvate dioxygenase [ Homo sapiens ]
Official Symbol: HPD
Synonyms: HPD; 4-hydroxyphenylpyruvate dioxygenase; PPD; 4 HPPD; 4HPPD; GLOD3; glyoxalase domain containing 3; 4-hydroxyphenylpyruvic acid oxidase; 4-HPPD; HPPDASE;
Gene ID: 3242
mRNA Refseq: NM_001171993
Protein Refseq: NP_001165464
MIM: 609695
UniProt ID: P32754
Chromosome Location: 12q14-qter
Pathway: Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Phenylalanine and tyrosine catabolism, organism-specific biosystem; Phenylalanine metabolism, organism-specific biosystem; Phenylalanine metabolism, conserved biosystem; Tyrosine degradation, tyrosine =>
Function: 4-hydroxyphenylpyruvate dioxygenase activity; 4-hydroxyphenylpyruvate dioxygenase activity; metal ion binding;

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