Recombinant Human HYAL3, His-tagged

• Cat.No.: HYAL3-14020H
• Product Overview: Recombinant Human HYAL3 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-350a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: HYAL3 hyaluronoglucosaminidase 3 [ Homo sapiens ]
• Official Symbol: HYAL3
• Synonyms: HYAL3; hyaluronoglucosaminidase 3; hyaluronidase-3; LUCA 3; LUCA14; Minna14; lung carcinoma protein 3; LUCA3; HYAL-3; LUCA-3
• Gene ID: 8372
• mRNA Refseq: NM_001200029
• Protein Refseq: NP_001186958
• MIM: 604038
• UniProt ID: O43820
• Chromosome Location: 3p21.3
• Pathway: Chondroitin sulfate degradation, organism-specific biosystem; Chondroitin sulfate degradation, conserved biosystem; Dermatan sulfate degradation, organism-specific biosystem; Dermatan sulfate degradation, conserved biosystem; Glycosaminoglycan degradation, organism-specific biosystem; Glycosaminoglycan degradation, conserved biosystem; Metabolic pathways, organism-specific biosystem
• Function: hyaluronoglucuronidase activity; hyalurononglucosaminidase activity; NOT hyalurononglucosaminidase activity; hydrolase activity, acting on glycosyl bonds; NOT viral receptor activity