"IKZF3" Related Products

Recombinant Human IKZF3, His-tagged

Cat.No.: IKZF3-14138H
Product Overview: Recombinant Human IKZF3 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
Source: E.coli
Species: Human
Tag: His
Protein length: 209-509a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: IKZF3 IKAROS family zinc finger 3 (Aiolos) [ Homo sapiens ]
Official Symbol: IKZF3
Synonyms: IKZF3; IKAROS family zinc finger 3 (Aiolos); zinc finger protein, subfamily 1A, 3 (Aiolos) , ZNFN1A3; zinc finger protein Aiolos; Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; AIOLOS; ZNFN1A3;
Gene ID: 22806
mRNA Refseq: NM_001257408
Protein Refseq: NP_001244337
MIM: 606221
UniProt ID: Q9UKT9
Chromosome Location: 17q11.2
Pathway: IL2-mediated signaling events, organism-specific biosystem;
Function: metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; zinc ion binding;

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