"EPO" Related Products

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Recombinant Human EPO, His-tagged

Cat.No.: EPO-2291H
Product Overview: Recombinant human EPO protein, fused to His-tag at N-terminus, was expressed in E.coli.
Description: Erythropoietin, also known as EPO, is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine hormone composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. Overexpression of EPO is associated with several pathophysiological conditions, such as polycythemias vera, which is caused by the EPO -independent growth of erythrocytic progenitors from abnormal stem cells.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Molecular Mass: 20.9 kDa
Protein length: 189aa
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSAPPRLIC DSRVLERYLL EAKEAENITT GCAEHCSLNE NITVPDTKVN FYAWKRMEVG QQAVEVWQGLALLSEAVLRG QALLVNSSQP WEPLQLHVDK AVSGLRSLTT LLRALRAQKE AISPPDAASA APLRTITADT FRKLFRVYSN FLRGKLKLYT GEACRTGDR
Purity: >80% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml
Gene Name: EPO erythropoietin [ Homo sapiens ]
Official Symbol: EPO
Synonyms: EPO; erythropoietin; EP; epoetin; MVCD2; MGC138142;
Gene ID: 2056
mRNA Refseq: NM_000799
Protein Refseq: NP_000790
MIM: 133170
UniProt ID: P01588
Chromosome Location: 7q21
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; EPO Receptor Signaling, organism-specific biosystem; EPO signaling pathway, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem;
Function: erythropoietin receptor binding; eukaryotic cell surface binding; hormone activity; protein binding; protein kinase activator activity;

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