Recombinant Human CARD17 protein, His-tagged

• Cat.No.: CARD17-2311H
• Product Overview: Recombinant Human CARD17(1-110aa) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: CARD17 is a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. This protein inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, CARD17 do not induce NF-kappa-B activation.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
• Molecular Mass: 14.3 kDa (133aa) confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMADKVLK EKRKQFIRSV GEGTINGLLG ELLETRVLSQ EEIEIVKCEN ATVMDKARAL LDSVIRKGAPACQICITYIC EEDSHLAGTL GLSAGPTSGN HLTTQDSQIV LPS
• Purity: > 95% by SDS - PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 1.0 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: CARD17 caspase recruitment domain family, member 17 [ Homo sapiens ]
• Official Symbol: CARD17
• Synonyms: CARD17; caspase recruitment domain family, member 17; caspase recruitment domain-containing protein 17; INCA; Inhibitory CARD; caspase-1 inhibitor INCA; inhibitory caspase recruitment domain protein; inhibitory caspase recruitment domain (CARD) protein
• Gene ID: 440068
• mRNA Refseq: NM_001007232
• Protein Refseq: NP_001007233
• MIM: 609490
• UniProt ID: Q5XLA6
• Chromosome Location: 11q22.3
• Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Immune System, organism-specific biosystem; Inflammasomes, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Interleukin-1 processing, organism-specific biosystem
• Function: cysteine-type endopeptidase activity; cysteine-type endopeptidase inhibitor activity; peptidase inhibitor activity