"Il4" Related Products

Recombinant Mouse Il4

Cat.No. : Il4-297M
Product Overview : Recombinant Mouse Il4 was expressed in CHO Cells.
Description : Interleukin-4 (IL-4) is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. It has important effects on the growth and differentiation of different immunologically competent cells. Interleukin-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of native CD4+ T cells (Th0 cells) into helper Th2 cells, and regulates the immunoglobulin class switching to the IgG1 and IgE isotypes. IL-4 has numerous important biological functions including stimulating B-cells activation, T-cell proliferation and CD4+ T-cells differentiation to Th2 cells. It is a key regulator in hormone control and adaptive immunity. IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells. IL-4 is stabilized by three disulphide bonds forming a compact globular protein structure. Four alpha-helix bundle with left-handed twist is dominated half of the protein structure with 2 overhand connections and fall into a 2-stranded anti-parallel beta sheet.
Source : CHO Cells
Species : Mouse
Form : Lyophilized after extensive dialysis against PBS.
Bio-activity : ED50< 2 ng/ml, measured in a cell proliferation assay using murine ht-2 cells, corresponding to a specific activity of>5 x 105 units/mg.
Molecular Mass : 15 kDa, observed by reducing SDS-PAGE.
AA Sequence : His23-Ser140.
Endotoxin : < 0.2 eu/μg, determined by lal>
Purity : >95% as analyzed by SDS-PAGE and HPLC.
Storage : Lyophilized recombinant protein remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmIL-4 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Reconstitution : Reconstituted in ddH2O or PBS at 100 μg/ml.
Publication :
Gene Name : Il4 interleukin 4 [ Mus musculus ]
Official Symbol : Il4
Synonyms : IL4; interleukin 4; interleukin-4; IGG1 induction factor; B-cell growth factor 1; B-cell stimulatory factor 1; lymphocyte stimulatory factor 1; B-cell IgG differentiation factor; Il-4; BSF-1;
Gene ID : 16189
mRNA Refseq : NM_021283
Protein Refseq : NP_067258
UniProt ID : P07750
Pathway : Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem;
Function : cytokine activity; cytokine receptor binding; growth factor activity; interleukin-4 receptor binding;

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