Active Recombinant Mouse St14, His-tagged
Cat.No. : | St14-210M |
Product Overview : | Recombinant Mouse St14 (Gly596-Val855) fused with an N-terminal Met and 6-His tag, was expressed in E. coli. |
- Specification
- Gene Information
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Description : | Suppressor of tumorigenicity 14 protein, also known asmatriptase, is aprotein that in humans is encoded by the ST14 gene. ST14 orthologs have been identified in most mammals for which complete genome data are available. |
Source : | E. coli |
Species : | Mouse |
Tag : | His |
Predicted N Terminal : | Met & Val615 |
Formulation : | Supplied as a 0.2 µm filtered solution in Tris and Glycerol. |
Bio-activity : | Measured by its ability to cleave the fluorogenic peptide substrate Boc-QAR-AMC. The specific activity is >4,000 pmol/min/µg. |
Molecular Mass : | 3 kDa & 26 kDa |
Endotoxin : | < 1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >75%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening. |
Gene Name : | St14 suppression of tumorigenicity 14 (colon carcinoma) [ Mus musculus (house mouse) ] |
Official Symbol : | St14 |
Synonyms : | St14; mCAP3; MT-SP1; Prss14; Epithin; Tmprss14; matriptase; suppression of tumorigenicity 14 (colon carcinoma); suppressor of tumorigenicity 14 protein homolog; matriptase/MT-SP1; serine protease 14; protease, serine, 14 (epithin); EC 3.4.21.109 |
Gene ID : | 19143 |
mRNA Refseq : | NM_011176 |
Protein Refseq : | NP_035306 |
UniProt ID : | P56677 |
Chromosome Location : | 9 A4; 9 16.61 cM |
Function : | catalytic activity; hydrolase activity; peptidase activity; serine-type endopeptidase activity |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIt regulates proteolytic activity, contributing to cellular processes like proliferation, differentiation, and migration.
ST14 is predominantly expressed in epithelial tissues and is also found in immune cells.
Mutations and altered expression of ST14 have been associated with various types of cancers.
ST14 activates the EGFR pathway by cleaving and activating pro-heparin-binding EGF-like growth factor (pro-HB-EGF).
Therapeutic strategies include developing ST14 inhibitors to prevent its pro-tumorigenic activities in cancer.
Overexpression of ST14 is linked to cancer progression, enhancing tumor cell invasion and metastasis.
ST14 (matriptase) is a type II transmembrane serine protease involved in the activation of other proteases and growth factors.
Customer Reviews (3)
Write a reviewWorked well in research.
Great product, excellent quality.
Reliable, high-quality product.
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