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Active Recombinant Mouse St14, His-tagged

Cat.No. : St14-210M
Product Overview : Recombinant Mouse St14 (Gly596-Val855) fused with an N-terminal Met and 6-His tag, was expressed in E. coli.
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  • Gene Information
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Description : Suppressor of tumorigenicity 14 protein, also known asmatriptase, is aprotein that in humans is encoded by the ST14 gene. ST14 orthologs have been identified in most mammals for which complete genome data are available.
Source : E. coli
Species : Mouse
Tag : His
Predicted N Terminal : Met & Val615
Formulation : Supplied as a 0.2 µm filtered solution in Tris and Glycerol.
Bio-activity : Measured by its ability to cleave the fluorogenic peptide substrate Boc-QAR-AMC. The specific activity is >4,000 pmol/min/µg.
Molecular Mass : 3 kDa & 26 kDa
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >75%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.
Gene Name : St14 suppression of tumorigenicity 14 (colon carcinoma) [ Mus musculus (house mouse) ]
Official Symbol : St14
Synonyms : St14; mCAP3; MT-SP1; Prss14; Epithin; Tmprss14; matriptase; suppression of tumorigenicity 14 (colon carcinoma); suppressor of tumorigenicity 14 protein homolog; matriptase/MT-SP1; serine protease 14; protease, serine, 14 (epithin); EC 3.4.21.109
Gene ID : 19143
mRNA Refseq : NM_011176
Protein Refseq : NP_035306
UniProt ID : P56677
Chromosome Location : 9 A4; 9 16.61 cM
Function : catalytic activity; hydrolase activity; peptidase activity; serine-type endopeptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does ST14 contribute to the regulation of protease activity? 06/12/2022

It regulates proteolytic activity, contributing to cellular processes like proliferation, differentiation, and migration.

In which cells or tissues is ST14 predominantly expressed? 04/04/2022

ST14 is predominantly expressed in epithelial tissues and is also found in immune cells.

Are there known genetic mutations or alterations in ST14 associated with specific diseases? 03/12/2022

Mutations and altered expression of ST14 have been associated with various types of cancers.

What role does ST14 play in the epidermal growth factor receptor (EGFR) signaling pathway? 01/27/2022

ST14 activates the EGFR pathway by cleaving and activating pro-heparin-binding EGF-like growth factor (pro-HB-EGF).

What therapeutic strategies are being explored targeting ST14 for disease treatment? 12/14/2020

Therapeutic strategies include developing ST14 inhibitors to prevent its pro-tumorigenic activities in cancer.

How is ST14 implicated in cancer progression and metastasis? 05/16/2020

Overexpression of ST14 is linked to cancer progression, enhancing tumor cell invasion and metastasis.

What is the primary function of the ST14 protein in cellular processes? 04/28/2020

ST14 (matriptase) is a type II transmembrane serine protease involved in the activation of other proteases and growth factors.

Customer Reviews (3)

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Reviews
04/08/2022

    Worked well in research.

    07/14/2021

      Great product, excellent quality.

      02/10/2021

        Reliable, high-quality product.

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