Recombinant human MLF1IP, His-tagged

• Cat.No.: MLF1IP-2495H
• Product Overview: Recombinant human MLF1IP protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Description: MLF1IP, as known as centromere, is a specialized chromatin domain, present throughout the cell cycle that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. It plays an important role in the correct PLK1 localization to the mitotic kinetochores. It is a scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. It also involved in transcriptional repression.
• Source: E.coli
• Species: Human
• Tag: His
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea
• Molecular Mass: 33.7kDa (295aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSTRRKVKS AEKISTQRHE VIRTTASSEL SEKPAESVTS KKTGPLSAQP SVEKENLAIE SQSKTQKKGKISHDKRKKSR SKAIGSDTSD IVHIWCPEGM KTSDIKELNI VLPEFEKTHL EHQQRIESKV CKAAIATFYV NVKEQFIKML KESQMLTNLKRKNAKMISDI EKKRQRMIEV QDELLRLEPQ LKQLQTKYDE LKERKSSLRN AAYFLSNLKQ LYQDYSDVQA QEPNVKETYD SSSLPALLFKARTLLGAESH LRNINHQLEK LLDQG
• Purity: >80% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: MLF1IP?MLF1 interacting protein [?Homo sapiens?(human) ]
• Official Symbol: MLF1IP
• Synonyms: MLF1IP; CENPU; KLIP1; PBIP1; CENP50; CENPU50; MLF1 interacting protein; centromere protein U; MLF1-interacting protein; centromere protein of 50 kDa; polo-box-interacting protein 1; interphase centromere complex protein 24; KSHV latent nuclear antigen interacting protein 1; KSHV latent nuclear antigen-interacting protein 1
• Gene ID: 79682
• mRNA Refseq: NM_024629
• Protein Refseq: NP_078905
• MIM: 611511
• UniProt ID: Q71F23
• Chromosome Location: 4q35.1
• Pathway: Cell Cycle; Chromosome Maintenance; Deposition of New CENPA-containing Nucleosomes at the Centromere