Active Recombinant Human LAG3, Fc-tagged

• Cat.No.: LAG3-102H
• Product Overview: The sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1.

Specification

• Description: Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.
• Source: CHO cells
• Species: Human
• Tag: Fc
• Form: Liquid. In PBS.
• Bio-activity: Inhibits binding of MAb to LAG-3 (human) to LAG-3. Induces maturation of human dendritic cells.
• Molecular Mass: ~80kDa (SDS-PAGE)
• Endotoxin: <0.1EU/μg purified protein
• Purity: ≥99% (SDS-PAGE)
• Applications: Flow Cytometry: Detection of MHC class II molecules in combination with fluorescently labeled antibodies to IgG1.
• Stability: Stable for at least 6 months after receipt when stored at -20°C.
• Storage: Short Term Storage +4°C Long Term Storage -20°C
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: LAG3 lymphocyte-activation gene 3 [ Homo sapiens (human) ]
• Official Symbol: LAG3
• Synonyms: LAG3; CD223; lymphocyte-activation gene 3; lymphocyte activation gene 3 protein
• Gene ID: 3902
• mRNA Refseq: NM_002286
• Protein Refseq: NP_002277
• MIM: 153337
• UniProt ID: P18627
• Chromosome Location: 12p13.32
• Function: MHC class II protein binding; antigen binding; transmembrane signaling receptor activity