Human CX3CL1, Biotin-tagged CX3CL1-103H

Human CX3CL1, Biotin-tagged

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Human CX3CL1, Biotin-tagged

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Cat.No. : CX3CL1-103H
Product Overview : It is a synthetic Protein with Biotin tag.
Description : Fractalkine, also termed neurotactin, is a membrane-bound CX3C chemokine. The mature protein is part of a 397-amino acid precursor consisting of a chemokine domain (76 amino acids), a mucin stalk of 241 residues, a putative transmembrane domain (18 amino acids), and an intracellular tail of 37 amino acids. Within the chemokine domain the first two cysteine residues are separated by 3 amino acids. Fractalkine message is found at high concentrations in the brain, and also in kidney, lung and heart. Fractalkine is chemotactic for monocytes and may play a role in brain inflammation. Product provided is the 76 amino acid chemokine domain with a C-terminal biotin.
Species : Human
Tag : Biotin
Form : Lyophilized
Bio-activity : Activity determined by a chemotaxis assay using human monocytes. Chemotaxis was achieved using a concentration of 10ng/ml. Optimal concentration should be evaluated by serial dilutions.
Applications : Activity Assay
Storage : Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Reconstitution : Recommended reconstitution in sterile phosphate buffered saline which contains at least 0.1% human or bovine serum albumin to prepare a stocksolution of no less than 20 μg/ml and vortex thoroughly.
Gene Name : CX3CL1 chemokine (C-X3-C motif) ligand 1 [ Homo sapiens ]
Official Symbol : CX3CL1
Synonyms : CX3CL1; chemokine (C-X3-C motif) ligand 1; SCYD1, small inducible cytokine subfamily D (Cys X3 Cys), member 1 (fractalkine, neurotactin); fractalkine; ABCD 3; C3Xkine; CXC3; CXC3C; neurotactin; NTN; C-X3-C motif chemokine 1; small-inducible cytokine D1; CX3C membrane-anchored chemokine; small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); NTT; SCYD1; ABCD-3;
Gene ID : 6376
mRNA Refseq : NM_002996
Protein Refseq : NP_002987
MIM : 601880
UniProt ID : P78423
Chromosome Location : 16q13
Pathway : Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Direct p53 effectors, organism-specific biosystem;
Function : chemokine activity; protein binding; receptor binding;

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