Active Human CCL19
Cat.No. : | CCL19-110H |
Product Overview : | It is a synthetic Protein |
- Specification
- Gene Information
- Related Products
Description : | MIP-3b is related to other b chemokines, possessing 20-30% sequence identity with other b proteins. MIP-3b has been mapped to the 9p13 chromosome. This differs from other b proteins which are mapped to chromosome 17. MIP-3b is expressed in a variety of lymphoid tissues. and is down-regulated by the anti-inflammatory cytokine IL-10. Synthetic MIP-3b is chemotactic for cultured human lymphocytes and is a unique functional ligand for CCR-7. The CCR-7 receptor has been previously referred to as the Epstein-Barr virus-induced gene 1 (EBI1). CCR-7 is a chemokine receptor which is expressed in various lymphoid tissues and activated B and T lymphocytes. EBI1 is strongly up-regulated in B cells infected with Epstein-Barr virus and T cells infected with herpesvirus 6 or 7. |
Species : | Human |
Form : | Lyophilized |
Bio-activity : | Activity measured by the protein's ability to chemoattract cultured human lymphocytes. ED50 for this activity is between 0.1 and 0.4 μg/ml |
AA Sequence : | GTNDAEDCCLSVTQKPIPGYIVRNF HYLLIKDGCRVPAVVFTTLRGRQLC APPDQPWVERIIQRLQRTSAKMKR RSS |
Applications : | Activity Assay |
Storage : | Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles |
Reconstitution : | Recommended reconstitution in sterile phosphate buffered saline which contains at least 0.1% human or bovine serum albumin to prepare a stocksolution of no less than 20 μg/ml and vortex thoroughly. |
Gene Name : | CCL19 chemokine (C-C motif) ligand 19 [ Homo sapiens ] |
Official Symbol : | CCL19 |
Synonyms : | CCL19; chemokine (C-C motif) ligand 19; SCYA19, small inducible cytokine subfamily A (Cys Cys), member 19; C-C motif chemokine 19; beta chemokine exodus 3; CC chemokine ligand 19; CK beta 11; CKb11; EBI1 ligand chemokine; ELC; exodus 3; macrophage inflammatory protein 3 beta; MIP 3b; exodus-3; CK beta-11; MIP-3-beta; EBI1-ligand chemokine; beta chemokine exodus-3; beta-chemokine exodus-3; small-inducible cytokine A19; macrophage inflammatory protein 3-beta; epstein-Barr virus-induced molecule 1 ligand chemokine; small inducible cytokine subfamily A (Cys-Cys), member 19; MIP3B; MIP-3b; SCYA19; MGC34433; |
Gene ID : | 6363 |
mRNA Refseq : | NM_006274 |
Protein Refseq : | NP_006265 |
MIM : | 602227 |
UniProt ID : | Q99731 |
Chromosome Location : | 9p13 |
Pathway : | Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem; |
Function : | CCR chemokine receptor binding; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding; chemokine activity; |
Products Types
◆ Recombinant Protein | ||
CCL19-510R | Recombinant Rhesus Macaque CCL19 Protein, His (Fc)-Avi-tagged | +Inquiry |
CCL19-014H | Recombinant Human CCL19 Protein, Biotinylated | +Inquiry |
CCL19-1391M | Recombinant Mouse CCL19 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ccl19-022C | Active Recombinant Mouse Ccl19 Protein (83 aa) | +Inquiry |
CCL19-1112H | Recombinant Horse CCL19 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CCL19-7729HCL | Recombinant Human CCL19 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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