Recombinant Human RALB, GST-tagged
Cat.No. : | RALB-117H |
Product Overview : | Recombinant Human RALB fused with?a GST tag, was expressed in E. Coli. |
- Specification
- Gene Information
- Related Products
Description : | RalB is a member of the Ras-like GTP binding protein family. Ras proteins provide a crucial link in the intracellular signalling cascades. Ras proteins are members of the small G protein family. These proteins are characterized by a molecular weight between 20 and 30 kDa, the ability to bind GTP or GDP and a low intrinsic GTPase activity. These proteins relay signals from the plasma membrane activated by receptor tyrosine kinases to the nucleus via a network of serine/threonine kinases. Ras proteins belong to a family of approximately 40 mammalian and 60 non-mammalian proteins. Ras proteins were first discovered as the hyperactive products of mutant Ras genes which promote cancer by disrupting the normal controls on cell proliferation and differentiation; about 30% of human cancers have mutations in a Ras gene. Ras and Ras-like proteins function as switches, cycling between 2 distinct conformational states, active when GTP is bound and inactive when GDP is bound. Affinity precipitation assays can be used to determine the activation status of Ras and Ras-like family members. This assay is based on the ability of the Ras family effector proteins to interact specifically with the activated GTP-bound form of their target GTPases. |
Source : | E. Coli |
Species : | Human |
Tag : | GST |
Form : | Provided in 50mM Tris (pH 7.5) solution containing 150 mM NaCl, 10 mM MgCl2, 1 mM DTT, 10% glycerol |
Applications : | Affinity Binding; Ral B protein is provided as a functional G-protein and can be used as a Western blot control for antibodies to Ral B protein or in assays to study to protein-protein interactions of Ral B and related proteins with regulatory proteins. |
Storage : | Product should be stored at -70°C. Aliquot to avoid freeze/thaw cycles |
Gene Name : | RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) [ Homo sapiens ] |
Official Symbol : | RALB |
Synonyms : | RALB; v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein); ras-related protein Ral-B; RAS-like protein B; GTP binding protein; |
Gene ID : | 5899 |
mRNA Refseq : | NM_002881 |
Protein Refseq : | NP_002872 |
MIM : | 179551 |
UniProt ID : | P11234 |
Chromosome Location : | 2q14.2 |
Pathway : | CXCR4-mediated signaling events, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; NGF signalling via TRKA from the plasma membrane, organism-specific biosystem; Pancreatic cancer, organism-specific biosystem; Pancreatic cancer, conserved biosystem; Pathways in cancer, organism-specific biosystem; Signal Transduction, organism-specific biosystem; |
Function : | GTP binding; GTP binding; GTPase activity; GTPase activity; nucleotide binding; protein binding; |
Products Types
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◆ Lysates | ||
RALB-2543HCL | Recombinant Human RALB 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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