| Cat.No.: | IL17BR-212H |
| Product Overview: | A DNA sequence encoding the human IL17BR (NP_061195.2) (Met1-Gly289) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Description: | Interleukin-17 receptor B, also known as IL-17 receptor B, IL-17RB, Cytokine receptor-like 4, IL-17 receptor homolog 1, Interleukin-17B receptor, IL-17B receptor, IL17RB and CRL4, is a secreted and single-pass type I membrane protein which contains one SEFIR domain. IL-17B receptor / IL17RB is expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines. IL-17B receptor / IL17RB is a receptor for the proinflammatory cytokines IL17B and IL17E. IL-17B receptor / IL17RB does not bind to IL17 and IL17C. IL-17B receptor / IL17RB may play a role in controlling the growth and / or differentiation of hematopoietic cells. IL-17B receptor / IL17RB has also been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. |
| Source: | Human Cells |
| Species: | Human |
| Tag: | Fc |
| Predicted N Terminal: | Arg 18 |
| Form: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. |
| Molecular Mass: | The recombinant human IL17BR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 513 amino acids and has a predicted molecular mass of 56.9 kDa. The apparent molecular mass of the protein is approximately 67 kDa in SDS-PAGE under reducing conditions. |
| Endotoxin: | < 1.0 eu per μg of the protein as determined by the lal |
| Purity: | >85 % as determined by SDS-PAGE |
| Stability: | Samples are stable for up to twelve months from date of receipt at -70℃ |
| Storage: | Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Gene Name: | IL17RB?interleukin 17 receptor B [?Homo sapiens?(human) ] |
| Official Symbol: | IL17RB |
| Synonyms: | IL17RB; CRL4; EVI27; IL17BR; IL17RH1; interleukin 17 receptor B; interleukin-17 receptor B; IL-17RB; IL-17Rh1; IL-17B receptor; IL-17 receptor B; cytokine receptor CRL4; IL-17 receptor homolog 1; cytokine receptor-like 4; interleukin 17B receptor; interle |
| Gene ID: | 55540 |
| mRNA Refseq: | NM_018725 |
| Protein Refseq: | NP_061195 |
| MIM: | 605458 |
| UniProt ID: | Q9NRM6 |
| Chromosome Location: | 3p21.1 |
| Pathway: | Cytokine-cytokine receptor interaction |
| Function: | cytokine receptor activity |
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