Recombinant Human AMIGO2, His tagged
Cat.No. : | AMIGO2-568H |
Product Overview : | Recombinant Human AMIGO2 (NP_862830.1) (Met1-Thr398), fused with a polyhistidine tag at the C-terminus, was produced in Human Cells. |
- Specification
- Gene Information
- Related Products
Source : | Human Cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Val 40 |
Form : | Lyophilized from sterile PBS, pH 7.4Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. |
Molecular Mass : | The recombinant human AMIGO2 consists of 370 amino acids and predicts a molecular mass of 42.3 KDa. It migrates as an approximately 58-63 KDa band in SDS-PAGE under reducing conditions. |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >95 % as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70oC. |
Storage : | Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | AMIGO2 adhesion molecule with Ig-like domain 2 [ Homo sapiens ] |
Official Symbol : | AMIGO2 |
Gene ID : | 347902 |
mRNA Refseq : | NM_181847 |
Protein Refseq : | NP_862830 |
UniProt ID : | Q86SJ2 |
Chromosome Location : | 12q13.11 |
Products Types
◆ Recombinant Protein | ||
AMIGO2-309R | Recombinant Rat AMIGO2 Protein, His (Fc)-Avi-tagged | +Inquiry |
AMIGO2-653R | Recombinant Rat AMIGO2 Protein | +Inquiry |
AMIGO2-4384C | Recombinant Chicken AMIGO2 | +Inquiry |
AMIGO2-568HB | Recombinant Human AMIGO2 protein, His-tagged, Biotinylated | +Inquiry |
AMIGO2-0019H | Recombinant Human AMIGO2 Protein (Val40-His393), C-His-tagged | +Inquiry |
◆ Lysates | ||
AMIGO2-1147HCL | Recombinant Human AMIGO2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAltered expression or dysregulation of AMIGO2 has been associated with neurological disorders, including autism spectrum disorders and epilepsy, highlighting its potential role in disease pathogenesis.
AMIGO2 exhibits a dynamic expression pattern in the developing and adult brain, with high expression in regions involved in neuronal development, such as the cortex, hippocampus, and cerebellum.
Knockout or overexpression studies of AMIGO2 have revealed its essential role in neuronal development and function, impacting processes such as neurite outgrowth, synaptogenesis, and neuronal survival.
AMIGO2 is involved in modulating synaptic plasticity and neurotransmission, regulating the activity and surface expression of neurotransmitter receptors and contributing to the refinement of synaptic connectivity.
AMIGO2 influences dendritic arborization and synaptic connectivity, promoting dendritic branching and the formation of mature dendritic spines, which are crucial for synaptic transmission and plasticity.
AMIGO2 plays a role in myelination and oligodendrocyte development, contributing to proper myelin sheath formation and the maturation of oligodendrocytes.
Modulation of AMIGO2 expression or activity holds potential as a therapeutic approach for neurological conditions, and further investigation into its specific mechanisms and interactions may unveil novel strategies for intervention and treatment.
AMIGO2 is involved in axon guidance and pathfinding, guiding axons to their appropriate targets during neuronal development, and contributing to the establishment of neuronal circuitry.
AMIGO2 plays a critical role in neuronal migration during brain development, regulating the proper positioning and layering of neurons in the developing cerebral cortex.
AMIGO2 interacts with various cell adhesion molecules and signaling proteins, including members of the immunoglobulin superfamily and growth factor receptors, activating downstream signaling pathways involved in cell adhesion, cytoskeletal remodeling, and synaptic plasticity.
Customer Reviews (3)
Write a reviewVersatility in multiple assay formats and platforms.
Excellent reproducibility in protein expression profiling.
Stable reagents for long-term storage and repeated use.
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