Recombinant Human CYP2C8


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Recombinant Human CYP2C8

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Cat. No. : CYP2C8-384H
Product Overview : Baculovirus-insect cell expressed with supplemental cDNA expressed human reductase and cytochrome b5. The incorporation of cytochrome b5 in these microsomes increases the cytochrome P450 activity.
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.
Source : baculovirus-insect cells
Form : Liquid; Frozen
Available size : 0.5 nmole P450 in 0.5 ml
Representative totalprotein concentration : 3.0 mg/ml.
Representative P450content : 370 pmole/mg.
Representative b5content : 590 pmole/mg.
Catalytic assay : paclitaxel-6(alpha)-hydroxylase activity
Representative catalyticassay : 2,200 pmole/(mg x min)
Storage : –80°C
OfficialSymbol : CYP2C8
Gene Name : CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 [Homo sapiens (human) ]
Synonyms : CYP2C8; CPC8; CYPIIC8; MP-12/MP-20; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450 2C8; P450 form 1; cytochrome P450 IIC2; cytochrome P450 MP-12; cytochrome P450 MP-20; cytochrome P450 form 1; microsomal monooxygenase; xenobiotic monooxygenase; s-mephenytoin 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; EC
Gene ID : 1558
mRNA Refseq : NM_000770
Protein Refseq : NP_000761
MIM : 601129
UniProt ID : P10632
Chromosome Location : 10q23.33
Pathway : Arachidonate Epoxygenase / Epoxide Hydrolase; Arachidonic acid metabolism; Biological oxidations
Function : aromatase activity; caffeine oxidase activity; electron carrier activity

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