Recombinant Human CYP2A6 CYP2A6-125H

Recombinant Human CYP2A6


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Recombinant Human CYP2A6

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Cat. No. : CYP2A6-125H
Product Overview : Recombinant Human CYP2A6 is baculovirus-insect cell expressed with supplemental cDNA expressed human reductase and human cytochrome b5.
Description : This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.
Source : baculovirus-insect cells
Form : Liquid; Frozen
Available size : 0.5 nmole P450 in 0.5 ml
Representative totalprotein concentration : 5.3 mg/ml
Representative P450 concentration : 190 pmole/mg
Representative cytochromeb5 concentration : 470 pmole/mg
Representativecatalytic assay : coumarin 7-hydroxylase activity, 4,200 pmol/(mg x min), 22 pmol/pmolP450/min
Storage : –80°C
OfficialSymbol : CYP2A6
Gene Name : CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 [ Homo sapiens ]
Synonyms : CYP2A6; CPA6; CYP2A; CYP2A3; P450PB; CYPIIA6; P450C2A; cytochrome P450, family 2, subfamily A, polypeptide 6; cytochrome P450 2A6; cytochrome P450(I); cytochrome P450 IIA3; coumarin 7-hydroxylase; xenobiotic monooxygenase; 1,4-cineole 2-exo-monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; EC
Gene ID : 1548
mRNA Refseq : NM_000762
Protein Refseq : NP_000753
MIM : 122720
UniProt ID : P11509
Chromosome Location : 19q13.2
Pathway : Biological oxidations; Caffeine metabolism; Chemical carcinogenesis
Function : aromatase activity; coumarin 7-hydroxylase activity; electron carrier activity; enzyme binding

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