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Rcombinant Rat Clec14a, Fc-tagged

Cat.No.: Clec14a-15R
Product Overview: A DNA sequence encoding the rat CLEC14A (Met1-Thr398) was expressed with the Fc region of human IgG1 at the C-terminus.
Description: C-type lectin domain family 14 member A, also known as Epidermal growth factor receptor 5 and CLEC14A, is a member of the C-type lectin domain (CTLD) family that contains one c-type lectin domain and one EGF-like domain. Mouse CLEC14A is a single-pass type I membrane protein. Members of the C-type lectin domain (CTLD) superfamily are metazoan proteins functionally important in glycoprotein metabolism, mechanisms of multicellular integration and immunity. They share a common fold and are involved in a variety of functions, such as generalized defense mechanisms against foreign agents, discrimination between healthy and pathogen-infected cells, and endocytosis and blood coagulation. Genome-level studies on human, elegans and melanogaster demonstrated almost complete divergence among invertebrate and mammalian families of CTLD-containing proteins (CTLDcps). The vertebrate CTLDcp families were essentially formed early in vertebrate evolution and are completely different from the invertebrate families. The composition of the CTLDcp superfamily in fish and mammals suggests that large scale duplication events played an important role in the evolution of vertebrates.
Source: Human Cells
Species: Rat
Tag: Fc
Predicted N Terminal: Glu 22
Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.
Molecular Mass: The recombinant rat CLEC14A/Fc is a disulfide-linked homodimer. The reduced monomer comprises 618 amino acids and has a predicted molecular mass of 67.6 kDa. The apparent molecular mass of the protein is approximately 110 and 37 kDa in SDS-PAGE under reducing conditions.
Endotoxin: < 1.0 eu per ug of the protein as determined by the lal
Purity: (75.4+12.7 )% as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Gene Name: Clec14a C-type lectin domain family 14, member A [ Rattus norvegicus ]
Official Symbol: Clec14a
Synonyms: CLEC14A; C-type lectin domain family 14, member A; C-type lectin domain family 14 member A; RGD1306232;
Gene ID: 314148
mRNA Refseq: NM_001014077
Protein Refseq: NP_001014099
Function: binding; sugar binding;

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