Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human ACSS3, His-tagged

Cat.No. : ACSS3-18H
Product Overview : Recombinant Human Acyl-CoA Synthetase Short-Chain Family Member 3 Mitochondrial/ACSS3 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Ala30-Ala686) of Human ACSS3 fused with a polyhistidine tag at the C-terminus.
  • Specification
  • Gene Information
  • Related Products
Description : Acyl-CoA Synthetase Short-Chain Family Member 3 Mitochondrial (ACSS3) is a member of the ATP-dependent AMP-binding enzyme family. ACSS3 localizes to the mitochondrion and catalyzes acetate and CoA into diphosphate and acetyl-CoA using the ATP. ACSS3 activates acetate for lipid synthesis use or for energy generation. Two isoforms of the human protein are produced by alternative splicing.
Source : HEK293
Species : Human
Tag : His
AA Sequence : AGAALRALVVPGPRGGLGGRGCRAL SSGSGSEYKTHFAASVTDPERFWGK AAEQISWYKPWTKTL ENKHSPSTRWFVEGMLNICYNAVDR HIENGKGDKIAIIYDSPVTNTKATF TYKEVLEQVSKLAGV LVKHGIKKGDTVVIYMPMIPQAMYT MLACARIGAIHSLIFGGFASKELSS RIDHVKPKVVVTASF GIEPGRRVEYVPLVEEALKIGQHKP DKILIYNRPNMEAVPLAPGRDLDWD EEMAKAQSHDCVPVL SEHPLYILYTSGTTGLPKGVIRPTG GYAVMLHWSMSSIYGLQPGEVWWAA SDLGWVVGHSYICYG PLLHGNTTVLYEGKPVGTPDAGAYF RVLAEHGVAALFTAPTAIRAIRQQD PGAALGKQYSLTRFK TLFVAGERCDVETLEWSKNVFRVPV LDHWWQTETGSPITASCVGLGNSKT PPPGQAGKSVPGYNV MILDDNMQKLKARCLGNIVVKLPLP PGAFSGLWKNQEAFKHLYFEKFPGY YDTMDAGYMDEEGYL YVMSRVDDVINVAGHRISAGAIEES ILSHGTVADCAVVGKEDPLKGHVPL ALCVLRKDINATEEQ VLEEIVKHVRQNIGPVAAFRNAVFV KQLPKTRSGKIPRSALSAIVNGKPY KITSTIEDPSIFGHV EEMLKQAVDHHHHHH
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Gene Name : ACSS3 acyl-CoA synthetase short-chain family member 3 [ Homo sapiens ]
Official Symbol : ACSS3
Synonyms : ACSS3; acyl-CoA synthetase short-chain family member 3; acyl-CoA synthetase short-chain family member 3, mitochondrial; FLJ21963; AMP-binding enzyme, 33217;
Gene ID : 79611
mRNA Refseq : NM_024560
Protein Refseq : NP_078836
MIM : 614356
UniProt ID : Q9H6R3
Chromosome Location : 12q21.31
Pathway : Metabolic pathways, organism-specific biosystem; Propanoate metabolism, organism-specific biosystem; Propanoate metabolism, conserved biosystem; acetate conversion to acetyl-CoA, organism-specific biosystem; ethanol degradation II, organism-specific biosystem; ethanol degradation IV, organism-specific biosystem; oxidative ethanol degradation III, organism-specific biosystem;
Function : ATP binding; acetate-CoA ligase activity; ligase activity; nucleotide binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (10)

Ask a question
What is the significance of ACSS3 in cancer? 10/06/2022

ACSS3 has been found to be upregulated in certain cancers and is associated with tumor growth, progression, and metabolic reprogramming.

Can ACSS3 regulate gene expression? 01/10/2022

Yes, ACSS3 can influence gene expression through its role in protein acetylation, which can modify histones and transcription factors.

How is ACSS3 activity linked to cellular energy status? 07/19/2021

ACSS3 activity is sensitive to cellular energy levels, particularly levels of ATP (adenosine triphosphate), which is an indicator of energy availability.

How is ACSS3 expression regulated? 03/12/2021

ACSS3 expression can be regulated by various factors, including nutrient availability, cellular energy status, and transcriptional control.

What are the downstream metabolic pathways that utilize acetyl-CoA? 11/03/2020

Acetyl-CoA is involved in various metabolic processes, including the citric acid cycle (Krebs cycle), fatty acid synthesis, and protein acetylation.

Are there any diseases associated with ACSS3? 05/24/2020

Recent studies have linked dysregulation of ACSS3 to various diseases, including cancer, obesity, and metabolic disorders.

Are there commercially available antibodies or kits for detecting ACSS3 protein? 03/20/2020

Yes, there are commercially available antibodies and kits that can be used for detecting ACSS3 protein in biological samples, such as Western blotting or immunohistochemistry.

Can ACSS3 protein be expressed and purified using recombinant DNA technology? 09/28/2019

Yes, ACSS3 protein can be produced using recombinant DNA technology by cloning the ACSS3 gene into an expression vector and expressing it in a suitable host organism, such as bacteria or yeast.

How can the activity of ACSS3 be measured experimentally? 08/19/2018

The activity of ACSS3 can be measured through enzymatic assays that assess the conversion of acetate to acetyl-CoA in vitro, using purified ACSS3 protein or cell lysates.

What techniques are commonly used to purify ACSS3 protein for laboratory studies? 05/10/2018

Common techniques for purifying ACSS3 protein include affinity chromatography, size exclusion chromatography, and ion exchange chromatography.

Customer Reviews (5)

Write a review
Reviews
11/18/2022

    Unbeatable price for the exceptional quality of the protein. Service was impeccable.

    02/16/2021

      Outstanding quality at an affordable price. Impressed with the value for money.

      12/03/2020

        Versatile and compatible. Fits various experimental setups."

        05/07/2019

          "The performance of this protein is truly remarkable. Its consistent and reliable results have significantly contributed to the success of our research endeavors.

          08/29/2018

            It eliminates background noise and provides clear and interpretable data.

            Ask a Question for All ACSS3 Products

            Required fields are marked with *

            My Review for All ACSS3 Products

            Required fields are marked with *

            0

            Inquiry Basket

            cartIcon
            logo

            FOLLOW US

            Terms and Conditions        Privacy Policy

            Copyright © 2024 Creative BioMart. All Rights Reserved.

            Contact Us

            • /

            Stay Updated on the Latest Bioscience Trends