||Recombinant Human SH3 Domain-Containing Kinase-Binding Protein 1/SH3KBP1 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Met1-Lys665) of Human SH3KBP1 fused with a 6His tag at the C-terminus.
||SH3 Domain-Containing Kinase-Binding Protein 1 (SH3KBP1) contains 3 SH3 domains. SH3KBP1 is widely expressed in many tissues, it is also expressed in some cancer cell lines. SH3KBP1 plays a role in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases. SH3KBP1 is involved in regulation of ligand-dependent endocytosis of the IgE receptor and in the regulation of cellular stress response via the MAPK pathways. SH3KBP1 is also required for the control of cell shape and migration.
||MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPL TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGE VEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEG ANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKT EMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKL LPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDL QKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLS DRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHI SLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAVPSPLSSSLGTAGHRA NSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLR LQMEVNDIKKALQSKVDHHHHHH
||Less than 0.1 ng/μg (1 IEU/μg).
||Greater than 95% as determined by reducing SDS-PAGE.