Recombinant Human GZMM, His-tagged
Cat.No. : | GZMM-97H |
Product Overview : | Recombinant Human Granzyme M/GZMM is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Thr24-Ala257) of Human GZMM fused with a polyhistidine tag at the C-terminus. |
- Specification
- Gene Information
- Related Products
Description : | Granzyme M is a secreted protein that belongs to the peptidase S1 family of Granzyme subfamily. Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: Granzyme A, Granzyme B, Granzyme H, and Granzyme M. Granzyme M contains one peptidase S1 domain and is highly, constitutively expressed in activated natural killer (NK) cells. Granzyme M cleaves peptide substrates after methionine, leucine, and norleucine. Its physiological substrates include EZR, α-tubulins and the apoptosis inhibitor BIRC5/Survivin. Granzyme M promotes caspase activation and subsequent apoptosis of target cells. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
AA Sequence : | TQIIGGREVIPHSRPYMASLQRNGS HLCGGVLVHPKWVLTAAHCLAQRMA QLRLVLGLHTLDSPG LTFHIKAAIQHPRYKPVPALENDLA LLQLDGKVKPSRTIRPLALPSKRQV VAAGTRCSMAGWGLT HQGGRLSRVLRELDLQVLDTRMCNN SRFWNGSLSPSMVCLAADSKDQAPC KGDSGGPLVCGKGRV LAGVLSFSSRVCTDIFKPPVATAVA PYVSWIRKVTGRSAVDHHHHHH |
Endotoxin : | Less than 0.1 ng/μg (1 IEU/μg). |
Purity : | Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. |
Gene Name : | GZMM granzyme M (lymphocyte met-ase 1) [ Homo sapiens ] |
Official Symbol : | GZMM |
Synonyms : | GZMM; granzyme M (lymphocyte met-ase 1); granzyme M; LMET1; lymphocyte met ase 1; MET1; met-ase; HU-Met-1; lymphocyte met-ase 1; Met-1 serine protease; natural killer cell granular protease; |
Gene ID : | 3004 |
mRNA Refseq : | NM_005317 |
Protein Refseq : | NP_005308 |
MIM : | 600311 |
UniProt ID : | P51124 |
Chromosome Location : | 19p13.3 |
Function : | peptidase activity; serine-type endopeptidase activity; serine-type peptidase activity; |
Products Types
◆ Recombinant Protein | ||
GZMM-4526H | Recombinant Human GZMM Protein, GST-tagged | +Inquiry |
GZMM-3350H | Recombinant Human GZMM Protein (Ile26-Ala257), His tagged | +Inquiry |
Gzmm-651M | Recombinant Mouse Gzmm Protein, His/GST-tagged | +Inquiry |
GZMM-98H | Active Recombinant Human GZMM protein, His-tagged | +Inquiry |
Gzmm-652R | Recombinant Rat Gzmm Protein, His/GST-tagged | +Inquiry |
◆ Lysates | ||
GZMM-5666HCL | Recombinant Human GZMM 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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