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Recombinant Human HAl, His-tagged

Cat.No. : HAl-103H
Product Overview : Recombinant Human Histidase/HAL is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Met1-Leu657) of Human HAL fused with a 6His tag at the C-terminus.
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Description : Histidase (HAL) belongs to the PAL/Histidase family. Histidase deaminates histidine to urocanic acid, the first step in histidine degradation. It is closely related to the plant enzyme phenylalanine ammonia-lyase , but is absent in plants and viruses. HAL contains a unique cofactor called 4-methylidene-imidazole-5-one group (MIO), which is produced autocatalytically by a cyclization and dehydration of the three amino-acid residues alanine, serine and glycine, for its chain folding. Defects in HAL are the cause of histidinemia (HISTID). HISTID is characterized by decreased urocanic acid as well as increased histamine and histidine in body fluids.
Source : HEK293
Species : Human
Tag : His
Form : Supplied as a 0.2 μM filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5
AA Sequence : MPRYTVHVRGEWLAVPCQDAQLTVG WLGREAVRRYIKNKPDNGGFTSVDD AHFLVRRCKGLGLLD NEDRLEVALENNEFVEVVIEGDAMS PDFIPSQPEGVYLYSKYREPEKYIE LDGDRLTTEDLVNLG KGRYKIKLTPTAEKRVQKSREVIDS IIKEKTVVYGITTGFGKFARTVIPI NKLQELQVNLVRSHS SGVGKPLSPERCRMLLALRINVLAK GYSGISLETLKQVIEMFNASCLPYV PEKGTVGASGDLAPL SHLALGLVGEGKMWSPKSGWADAKY VLEAHGLKPVILKPKEGLALINGTQ MITSLGCEAVERASA IARQADIVAALTLEVLKGTTKAFDT DIHALRPHRGQIEVAFRFRSLLDSD HHPSEIAESHRFCDR VQDAYTLRCCPQVHGVVNDTIAFVK NIITTELNSATDNPMVFANRGETIS GGNFHGEYPAKALDY LAIGIHELAAISERRIERLCNPSLS ELPAFLVAEGGLNSGFMIAHCTAAA LVSENKALCHPSSVD SLSTSAATEDHVSMGGWAARKALRV IEHVEQVLAIELLAACQGIEFLRPL KTTTPLEKVYDLVRS VVRPWIKDRFMAPDIEAAHRLLLEQ KVWEVAAPYIEKYRMEHIPESRPLS PTAFSLQFLHKKSTK IPESEDLVDHHHHHH
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Storage : Store at Please minimize freeze-thaw cycles.
Gene Name : HAL histidine ammonia-lyase [ Homo sapiens ]
Official Symbol : HAl
Synonyms : HAL; histidine ammonia-lyase; HIS; histidase; HSTD;
Gene ID : 3034
mRNA Refseq : NM_001258333
Protein Refseq : NP_001245262
MIM : 609457
UniProt ID : P42357
Chromosome Location : 12q22-q24.1
Pathway : Histidine catabolism, organism-specific biosystem; Histidine metabolism, organism-specific biosystem; Histidine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; histidine degradation III, organism-specific biosystem;
Function : ammonia-lyase activity; catalytic activity; histidine ammonia-lyase activity; lyase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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