Recombinant Human PENK, His-tagged

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Recombinant Human PENK, His-tagged

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Cat.No. : PENK-177H
Product Overview : Recombinant Human Proenkephalin-A/PENK is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Glu25-Phe267) of Human PENK fused with a polyhistidine tag at the C-terminus.
Description : Proenkephalin-A is a secreted protein that belongs to the opioid neuropeptide precursor family. Proenkephalin-A is an endogenous opioid polypeptide hormone which, via proteolyic cleavage, produces the enkephalin peptides [Met]enkephalin, and to a lesser extent, [Leu]enkephalin. Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Proenkephalin-A (114-133) and Proenkephalin-A (237-258) increase glutamate release in the striatum. Proenkephalin-A (114-133) decreases GABA concentration in the striatum.
Source : HEK293
Species : Human
Tag : His
AA Sequence : ECSQDCATCS YRLVRPADIN FLACVMECEG KLPSLKIWET CKELLQLSKP ELPQDGTSTL RENSKPEESH LLAKRYGGFM KRYGGFMKKM DELYPMEPEE EANGSEILAK RYGGFMKKDA EEDDSLANSS DLLKELLETG DNRERSHHQD GSDNEEEVSK RYGGFMRGLK RSPQLEDEAK ELQKRYGGFM RRVGRPEWWM DYQKRYGGFL KRFAEALPSD EEGESYSKEV PEMEKRYGGF MRFVDHHHHH H
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Gene Name : PENK proenkephalin [ Homo sapiens ]
Official Symbol : PENK
Synonyms : PENK; proenkephalin; proenkephalin-A; preproenkephalin; enkephalin A;
Gene ID : 5179
mRNA Refseq : NM_001135690
Protein Refseq : NP_001129162
MIM : 131330
UniProt ID : P01210
Chromosome Location : 8q23-q24
Pathway : Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem;
Function : neuropeptide hormone activity; opioid peptide activity;

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