Recombinant Human TGFBRAP1, His-tagged

• Cat.No.: TGFBRAP1-5092H
• Product Overview: Recombinant human TGFBRAP1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Description: TGFBRAP1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. It may recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• Molecular Mass: 33 kDa (269aa)
• AA Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSKRLQ KEEYHTHLAV LYLEEVLLQR ASASGKGAEA TETQAKLRRL LQKSDLYRVH FLLERLQGAG LPMESAILHG KLGEHEKALH ILVHELQDFA AAEDYCLWCS EGRDPPHRQQ LFHTLLAIYL HAGPTAHELA VAAVDLLNRH ATEFDAAQVL QMLPDTWSVQ LLCPFLMGAM RDSIHARRTM QVALGLARSE NLIYTYDKMK LKGSSIQLSD KKLCQICQNP FCEPVFVRYP NGGLVHTHCA ASRHTNPSSS SPGTRT
• Purity: >80% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20centigrade or -70centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: TGFBRAP1 transforming growth factor, beta receptor associated protein 1 [ Homo sapiens (human) ]
• Official Symbol: TGFBRAP1
• Synonyms: TGFBRAP1;TRAP1; TRAP-1;transforming growth factor-beta receptor-associated protein 1;TGF-beta receptor-associated protein 1;TGF beta receptor associated protein -1
• Gene ID: 9392
• mRNA Refseq: NM_001142621.1
• Protein Refseq: NP_001136093.1
• MIM: 606237
• UniProt ID: Q8WUH2
• Chromosome Location: 2q12.1
• Function: SMAD binding;protein binding;small GTPase regulator activity;transforming growth factor beta receptor binding