Recombinant Human IFNB1 IFNB1-533H

Recombinant Human IFNB1

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Recombinant Human IFNB1

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Cat.No. : IFNB1-533H
Product Overview : Recombinant Human IFNB1 produced in E. coli is approximately 20.0 kDa, a single non-glycosylated polypeptide chain containing 166 amino acids.
Description : IFN-βs are proteins produced by many cell types including lymphocytes (NK cells, B-cells and T-cells), macrophages, fibroblasts, endothelial cells, osteoblasts and others. They have antiviral activity that it is mainly involved in innate immune response. The IFN-β family has 2 subtypes,which are IFN-β1 (IFNB1) and IFN-β3 (IFNB3) (a gene designated IFN-β2 is actually IL-6). IFN-β1 is used as a treatment for multiple sclerosis as it reduces the relapse rate.
Source : E. coli
Species : Human
Form : Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, containing 2% HSA and 3% mannitol.
Bio-activity : Fully biologically active when compared to standard. The specific activity determined by an anti-viral assay is no less than 3.2 × 10^7IU/mg.
Molecular Mass : 20 kDa
AA Sequence : MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN
Endotoxin : Less than 1EU/μg of rHuIFN-β1b as determined by LAL method.
Purity : >97% by SDS-PAGE and HPLC analyses.
Usage : This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage : This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution : We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : IFNB1 interferon, beta 1, fibroblast [ Homo sapiens ]
Official Symbol : IFNB1
Synonyms : IFNB1; interferon, beta 1, fibroblast; IFNB; interferon beta; IFB; IFF; IFN-beta; fibroblast interferon; MGC96956;
Gene ID : 3456
mRNA Refseq : NM_002176
Protein Refseq : NP_002167
MIM : 147640
UniProt ID : P01574
Chromosome Location : 9p22
Pathway : Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response, organism-specific biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem;
Function : cytokine activity; interferon-alpha/beta receptor binding; transcription corepressor activity;

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