"Defb3" Related Products

Recombinant Rat Defb3

Cat.No.: Defb3-597R
Product Overview: Recombinant Rat Defb3 produced in E. coli is approximately 4.5 kDa, a single non-glycosylated polypeptide chain containing 41 amino acid residues.
Description: Beta defensin-3, also known as BD-3 and DEFB-3, is a membrane active cationic peptide that functions in inflammation and innate immune responses and coded by Defb 3 gene on chromosome 8 in mouse. There are at least 30 β-defensins which are distinguished from α-defensins by the connectivity pattern of their three intramolecular disulfide bonds. BD3 is widely expressed among epithelial tissues, notably by keratinocytes and airway epithelial cells. It is upregulated in response to proinflammatory cytokines, microbial and viral infections, and at the edges of skin wounds. BD3 induction in osteoarthritis chondrocytes promotes MMP1 and 13 productions and inhibits TIMP1 and 2 expressions.
Source: E. coli
Species: Rat
Form: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Bio-activity: Fully biologically active when compared to standard. Measured by its antimicrobial activity against E. coli. The ED 50 for this effect is typically 4-20μg/ml.
Molecular Mass: 4.5 kDa
AA Sequence: KKVYNAVSCM TNGGICWLKC SGTFREIGSC GTRQLKCCKK K
Endotoxin: Less than 1 EU/μg of rRtBD-3 as determined by LAL method.
Purity: >95% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apport
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportion
Gene Name: Defb3 beta-defensin 3 [ Rattus norvegicus (Norway rat) ]
Official Symbol: Defb3
Synonyms: Defb3;beta-defensin 3;BD-3;defensin, beta 3
Gene ID: 641623
mRNA Refseq: NM_001037548.1
Protein Refseq: NP_001032637.1
UniProt ID: Q32ZI4
Chromosome Location: 16q12.4-q12.5
Pathway: Beta defensins;Defensins;Immune System;Innate Immune System

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