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Recombinant Rat Ccl4

Cat.No.: Ccl4-634R
Product Overview: Recombinant Rat Ccl4 produced in E. coli is approximately 7.8 kDa, a single non-glycosylated polypeptide chain containing 69 amino acids.
Description: Chemokine (C-C motif) ligand 4 encoded by the CCL4 gene, also known as macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors and it is a major HIV-suppressive factor produced by CD8+ T cells. In addition, it is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. Recombinant CCL4 induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). Furthermore, recombinant rat CCL4 contains 69 amino acids and it shares 80% and 86% a.a. sequence identity with human and murine CCL4. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells.
Source: E. coli
Species: Rat
Form: Lyophilized from a 0.2 μm filtered concentrated solution in 2 × PBS, pH 7.4, 3% trehalose
Bio-activity: Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 10-1000 ng/ml.
Molecular Mass: 7.8 kDa
AA Sequence: APIGSDPPTS CCFSYTSRKI HRNFVMDYYE TSSLCSQPAV VFLTKKGRQI CADPSEPWVN EYVNDLELN
Endotoxin: Less than 1 EU/μg of rRtMIP-1β/CCL4 as determined by LAL method.
Purity: >95% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name: Ccl4 chemokine (C-C motif) ligand 4 [ Rattus norvegicus ]
Official Symbol: Ccl4
Synonyms: CCL4; chemokine (C-C motif) ligand 4; C-C motif chemokine 4; MIP-1-beta; small inducible cytokine A4; small-inducible cytokine A4; macrophage inflammatory protein 1-beta; macrophage inflammatory protein-1 beta; Scya4; Mip1-b;
Gene ID: 116637
mRNA Refseq: NM_053858
Protein Refseq: NP_446310
Pathway: Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; Salmonella infection, organism-specific biosystem;
Function: CCR1 chemokine receptor binding; CCR5 chemokine receptor binding; chemokine activity; chemokine activity;

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