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Recombinant Human SNCB, His-tagged

Cat.No.: SNCB-246H
Product Overview: Recombinant full length human SNCB was expressed in E. coli cells using an N-terminal His tag.
Description: SNCB is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. SNCB is highly homologous to alpha-synuclein which is abundantly expressed in the brain and putatively inhibits phospholipase D2 selectively. SNCB may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. SNCB is shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease but no direct relation to Parkinson disease has been established. An alteration in SNCB may impair its normal inhibitory action on the formation of toxic alpha-synuclein fibrils, thereby indirectly contributing to disease pathogenesis.
Source: E. coli
Species: Human
Tag: His
Form: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Molecular Mass: ~19 kDa
Purity: >95% by densitometry
Applications: Western Blot
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.2 μg/μl
Gene Name: SNCB synuclein, beta [ Homo sapiens ]
Official Symbol: SNCB
Synonyms: SNCB; synuclein, beta; beta-synuclein;
Gene ID: 6620
mRNA Refseq: NM_001001502
Protein Refseq: NP_001001502
MIM: 602569
UniProt ID: Q16143
Chromosome Location: 5q35
Function: calcium ion binding; phospholipase inhibitor activity;

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