Recombinant Human BPTF, GST-tagged


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Recombinant Human BPTF, GST-tagged

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Cat.No. : BPTF-156H
Product Overview : Recombinant Human BPTF bromodomain (2796-2907 aa) fused to a GST tag at the N-terminus
Description : The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BPTF is the largest component of the NURF chromatin remodeling complex. It includes adjacent PHD and bromodomains which recognize trimethylation of H3K4 or acetylation of lysines in histone 4, respectively. BPTF is an essential regulator of gene expression in early mouse embryos, and its knock-out is embryonic lethal. Duplication of the BPTF gene has been suggested to increase proliferation of cultured cancer cells, and aberrant BPTF copy numbers were found in 42% of the “NCI-60” panel of 60 human cancer cell lines. This protein product contains the bromodomain of BPTF.
Source : E. coli
Species : Human
Tag : GST
Form : Liquid. 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.
Molecular Mass : 40.1 kDa (2796-2907 aa + NT GST Tag)
Purity : ≥80%
Storage : Store at -80°C. Avoid repeated freeze and thaw cycles. Stable for 1 year.
Gene Name : BPTF bromodomain PHD finger transcription factor [ Homo sapiens ]
Official Symbol : BPTF
Synonyms : BPTF; bromodomain PHD finger transcription factor; FALZ, fetal Alzheimer antigen; nucleosome-remodeling factor subunit BPTF; FAC1; NURF301; fetal Alzheimer antigen; fetal Alz-50 clone 1 protein; fetal Alz-50 reactive clone 1; nucleosome remodeling factor, large subunit; bromodomain and PHD domain transcription factor; bromodomain and PHD finger-containing transcription factor; FALZ;
Gene ID : 2186
mRNA Refseq : NM_004459
Protein Refseq : NP_004450
MIM : 601819
UniProt ID : Q12830
Chromosome Location : 17q24
Function : contributes_to DNA-dependent ATPase activity; metal ion binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding; transcription factor binding; zinc ion binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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