"PCSK2" Related Products

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Recombinant Human PCSK2, His-tagged

Cat.No.: PCSK2-88H
Product Overview: Recombinant Human PCSK2 (Gly110-Asn638) fused with 6­His tag at C­terminal, was expressed in CHO Cells.
Description: This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Source: CHO Cells
Species: Human
Tag: His
Predicted N Terminal: Gly110
Form: Supplied as a 0.2 µm filtered solution in Tris, NaCl and CaCl2.
Bio-activity: Measured by its ability to cleave the fluorogenic peptide substrate pERTKR-AMC. The specific activity is >60 pmol/min/µg, as measured under the described conditions.
Molecular Mass: 59 kDa
Endotoxin: < 1.0 EU per 1 μg of the protein by the LAL method.
Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.
Gene Name: PCSK2 proprotein convertase subtilisin/kexin type 2 [ Homo sapiens (human) ]
Official Symbol: PCSK2
Synonyms: PCSK2; PC2; NEC2; SPC2; NEC 2; NEC-2; proprotein convertase subtilisin/kexin type 2; neuroendocrine convertase 2; prohormone convertase 2; KEX2-like endoprotease 2; EC 3.4.21.94
Gene ID: 5126
mRNA Refseq: NM_002594
Protein Refseq: NP_002585
MIM: 162151
UniProt ID: P16519
Chromosome Location: 20p11.2
Pathway: Insulin Processing; Metabolism of proteins; Peptide hormone metabolism
Function: protein binding; protein complex binding; serine-type endopeptidase activity

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