Active Recombinant Human CIT, GST-tagged

• Cat.No.: CIT-827H
• Product Overview: Recombinant human STK21 (CIT) (1-449) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: STK21 is a serine/threonine-protein kinase that functions in cell division and also to promote efficient cytokinesis. STK21 is a novel molecular mechanism for a subset of human malformation syndromes of the central nervous system. STK21 is also associated with bipolar disorder and risk for schizophrenia. STK21 is a novel partner for the GTP-bound forms of rho and rac.
• Source: Sf9 insect cells using baculovirus
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 5 nmol/min/mg
• Molecular Mass: ~74 kDa
• Protein length: 1-449
• Purity: >70%
• Applications: Kinase Assay, Western Blot
• Stability: 1yr at –70°C from date of shipment
• Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1ug/ul

Gene Information

• Gene Name: CIT citron (rho-interacting, serine/threonine kinase 21) [ Homo sapiens ]
• Official Symbol: CIT
• Synonyms: CIT; citron (rho-interacting, serine/threonine kinase 21); citron Rho-interacting kinase; CRIK; KIAA0949; STK21; serine/threonine-protein kinase 21
• Gene ID: 11113
• mRNA Refseq: NM_001206999
• Protein Refseq: NP_001193928
• MIM: 605629
• UniProt ID: O14578
• Chromosome Location: 12q24.23
• Pathway: G13 Signaling Pathway, organism-specific biosystem
• Function: ATP binding; SH3 domain binding; metal ion binding; nucleotide binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity; small GTPase regulator activity