Active Recombinant Human ACE2, FLAG-tagged

• Cat.No.: ACE2-67H
• Product Overview: Signal peptide sequence and the extracellular domain of human ACE2 (aa 1-740) are fused at the C-terminus to a FLAG-tag.

Specification

• Description: ACE2 has direct effects on cardiac functions. It is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE2 converts angiotensin I to angiotensin 1-9. ACE2 was also identified as a functional receptor for SARS coronavirus.
• Source: HEK293 Cells
• Species: Human
• Tag: FLAG
• Form: Liquid. 0.2μm-filtered solution in PBS.
• Bio-activity: Converts angiotensin I to angiotensin-(1-9).
• Molecular Mass: ~90kDa (SDS-PAGE)
• Endotoxin: <0.1eu g purified protein (lal test; lonza).>
• Purity: ≥90% (SDS-PAGE)
• Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
• Concentration: 1mg/ml

Gene Information

• Gene Name: ACE2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 [ Homo sapiens ]
• Official Symbol: ACE2
• Synonyms: ACE2; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2; metalloprotease MPROT15; ACE-related carboxypeptidase; angiotensin I converting enzyme 2; angiotensin-converting enzyme homolog; ACEH
• Gene ID: 59272
• mRNA Refseq: NM_021804
• Protein Refseq: NP_068576
• MIM: 300335
• UniProt ID: Q9BYF1
• Chromosome Location: Xp22
• Pathway: ACE Inhibitor Pathway, organism-specific biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem; Renin-angiotensin system, organism-specific biosystem; Renin-angiotensin system, conserved biosystem
• Function: carboxypeptidase activity; endopeptidase activity; glycoprotein binding; metal ion binding; NOT metallopeptidase activity; peptidase activity; NOT peptidyl-dipeptidase activity; viral receptor activity; zinc ion binding