Active Recombinant Human ICAM1, Fc-tagged
Cat.No. : | ICAM1-146H |
Product Overview : | The extracellular domain of human CD54 [ICAM-1] (aa 28-480) is fused to the N-terminus of the Fc region of a mutant human IgG1. |
- Specification
- Gene Information
- Related Products
Description : | Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac1. CD54 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-γ, TNF-α, IL-1β and LPS. Soluble CD54 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation. |
Source : | CHO Cells |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Shows the biological function of the CD54 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. |
Purity : | ≥98% (SDS-PAGE) |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles. |
Gene Name : | ICAM1 intercellular adhesion molecule 1 [ Homo sapiens ] |
Official Symbol : | ICAM1 |
Synonyms : | ICAM1; intercellular adhesion molecule 1; BB2; CD54; human rhinovirus receptor; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; P3.58; |
Gene ID : | 3383 |
mRNA Refseq : | NM_000201 |
Protein Refseq : | NP_000192 |
MIM : | 147840 |
UniProt ID : | P05362 |
Chromosome Location : | 19p13.3-p13.2 |
Pathway : | Adaptive Immune System, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; |
Function : | cell surface binding; integrin binding; protein binding; receptor activity; transmembrane signaling receptor activity; |
Products Types
◆ Recombinant Protein | ||
ICAM1-2005R | Recombinant Rhesus Macaque ICAM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ICAM1-4320B | Recombinant Bovine ICAM1 Protein | +Inquiry |
ICAM1-1005R | Recombinant Rhesus ICAM1 Protein (Met1-Glu480), His-tagged | +Inquiry |
Icam1-4322M | Recombinant Mouse Icam1 Protein | +Inquiry |
ICAM1-292H | Recombinant Human ICAM1 Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
ICAM1-2655HCL | Recombinant Human ICAM1 cell lysate | +Inquiry |
ICAM1-1970RCL | Recombinant Rat ICAM1 cell lysate | +Inquiry |
ICAM1-2487MCL | Recombinant Mouse ICAM1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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