Recombinant Human KL, Fc-tagged
Cat.No. : | KL-386H |
Product Overview : | Signal peptide and the extracellular domain of human Klotho (aa 1-981) are fused at the C-terminus to the Fc portion of human IgG1. |
- Specification
- Gene Information
- Related Products
Description : | Klotho is involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. It is an essential factor for the specific interaction between FGF23 and FGFR1. The secreted Klotho protein can regulate multiple growth factor signaling pathways, including insulin/IGF-1 and Wnt, and the activity of multiple ion channels. Klotho protein protects cells and tissues from oxidative stress. Understanding of Klotho protein function is expected to provide new insights into the molecular basis for aging, phosphate/vitamin D metabolism, cancer and stem cell biology. |
Source : | HEK293 Cells |
Species : | Human |
Tag : | Fc |
Form : | Liquid. 0.2μm-filtered solution in PBS. |
Molecular Mass : | ~110kDa (SDS-PAGE) |
Purity : | ≥95% (SDS-PAGE) |
Stability : | Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
Concentration : | ~0.15mg/ml |
Gene Name : | KL klotho [ Homo sapiens ] |
Official Symbol : | KL |
Synonyms : | KL; klotho; |
Gene ID : | 9365 |
mRNA Refseq : | NM_004795 |
Protein Refseq : | NP_004786 |
UniProt ID : | Q9UEF7 |
Chromosome Location : | 13q12 |
Pathway : | Ascorbate biosynthesis, animals, glucose-1P => ascorbate, organism-specific biosystem; Ascorbate biosynthesis, animals, glucose-1P => ascorbate, conserved biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem; |
Function : | beta-glucosidase activity; beta-glucuronidase activity; cation binding; fibroblast growth factor binding; fibroblast growth factor receptor binding; hormone activity; signal transducer activity; vitamin D binding; |
Products Types
◆ Recombinant Protein | ||
KL-2922R | Recombinant Rat KL Protein, His (Fc)-Avi-tagged | +Inquiry |
KL-4828M | Recombinant Mouse KL Protein, His (Fc)-Avi-tagged | +Inquiry |
Kl-1714R | Recombinant Rat Kl Protein, His-tagged | +Inquiry |
KL-3220H | Recombinant Human KL Protein, His (Fc)-Avi-tagged | +Inquiry |
KL-1071H | Recombinant Human KL Protein, His&SUMO-tagged | +Inquiry |
◆ Lysates | ||
KL-4936HCL | Recombinant Human KL 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionKL protein may have a neuroprotective role and is being studied for its potential in preserving cognitive function and preventing neurodegenerative diseases.
Currently, there are no FDA-approved KL protein-based therapies, but research in this area is ongoing.
While research suggests a connection between KL protein and aging, it is not yet clear if KL protein supplementation can effectively slow down the aging process in humans.
KL protein levels can be measured in blood and urine samples using various laboratory techniques.
Yes, several clinical trials are investigating the potential therapeutic benefits of KL protein supplementation in kidney disease and other disorders.
Customer Reviews (3)
Write a reviewThe KL protein's reliability and ease of use have made it an essential component of my structural investigations.
Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.
Furthermore, the KL protein has demonstrated great utility in protein electron microscopy structure analysis.
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