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Recombinant Human KL, Fc-tagged

Cat.No.: KL-386H
Product Overview: Signal peptide and the extracellular domain of human Klotho (aa 1-981) are fused at the C-terminus to the Fc portion of human IgG1.
Description: Klotho is involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. It is an essential factor for the specific interaction between FGF23 and FGFR1. The secreted Klotho protein can regulate multiple growth factor signaling pathways, including insulin/IGF-1 and Wnt, and the activity of multiple ion channels. Klotho protein protects cells and tissues from oxidative stress. Understanding of Klotho protein function is expected to provide new insights into the molecular basis for aging, phosphate/vitamin D metabolism, cancer and stem cell biology.
Source: HEK293 Cells
Species: Human
Tag: Fc
Form: Liquid. 0.2μm-filtered solution in PBS.
Molecular Mass: ~110kDa (SDS-PAGE)
Purity: ≥95% (SDS-PAGE)
Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Concentration: ~0.15mg/ml
Gene Name: KL klotho [ Homo sapiens ]
Official Symbol: KL
Synonyms: KL; klotho;
Gene ID: 9365
mRNA Refseq: NM_004795
Protein Refseq: NP_004786
UniProt ID: Q9UEF7
Chromosome Location: 13q12
Pathway: Ascorbate biosynthesis, animals, glucose-1P => ascorbate, organism-specific biosystem; Ascorbate biosynthesis, animals, glucose-1P => ascorbate, conserved biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem;
Function: beta-glucosidase activity; beta-glucuronidase activity; cation binding; fibroblast growth factor binding; fibroblast growth factor receptor binding; hormone activity; signal transducer activity; vitamin D binding;

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