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Active Recombinant Mouse Lag3, Fc-tagged

Cat.No. : Lag3-389M
Product Overview : The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3).
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Description : Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Source : CHO Cells
Species : Mouse
Tag : Fc
Form : Liquid. In PBS.
Bio-activity : Induces maturation of mouse dendritic cells in vitro. Induces CD4 and CD8 antigen-specific T cells responses when coinjected s.c. in mice, together with the antigen.
Molecular Mass : ~180kDa (SPS-PAGE, nonreducing), ~80kDa (SPS-PAGE, reducing)
Purity : ≥95% (SDS-PAGE)
Stability : Stable for at least 6 months after receipt when stored at +4°C.
Storage : Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
Concentration : 0.5 mg/ml
Gene Name : Lag3 lymphocyte-activation gene 3 [ Mus musculus ]
Official Symbol : Lag3
Synonyms : LAG3; lymphocyte-activation gene 3; lymphocyte activation gene 3 protein; Ly66; CD223; LAG-3;
Gene ID : 16768
mRNA Refseq : NM_008479
Protein Refseq : NP_032505
Function : MHC class II protein binding; MHC class II protein binding; transmembrane signaling receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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