Recombinant Mouse Notch1, Fc-tagged
Cat.No. : | Notch1-435M |
Product Overview : | The extracellular domain of mouse Notch1 (aa 19-488) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1. |
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Description : | Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins. |
Source : | CHO Cells |
Species : | Mouse |
Tag : | Fc |
Form : | Lyophilized. Contains PBS. |
Molecular Mass : | ~85kDa (SDS-PAGE) |
Purity : | ≥95% (SDS-PAGE) |
Stability : | Stable for at least 6 months after receipt when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
Concentration : | 1mg/ml after reconstitution. |
Gene Name : | Notch1 Notch gene homolog 1 (Drosophila) [ Mus musculus ] |
Official Symbol : | Notch1 |
Synonyms : | NOTCH1; Notch gene homolog 1 (Drosophila); neurogenic locus notch homolog protein 1; mT14; p300; Motch A; notch 1; major type A protein; transmembrane receptor Notch1; N1; Mis6; Tan1; lin-12; 9930111A19Rik; |
Gene ID : | 18128 |
mRNA Refseq : | NM_008714 |
Protein Refseq : | NP_032740 |
Pathway : | Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Dorso-ventral axis formation, organism-specific biosystem; Dorso-ventral axis formation, conserved biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; |
Function : | chromatin DNA binding; chromatin binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; |
Products Types
◆ Recombinant Protein | ||
NOTCH1-127H | Recombinant Human NOTCH1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NOTCH1-5996H | Recombinant Human NOTCH1 Protein, GST-tagged | +Inquiry |
NOTCH1-2498H | Recombinant Human NOTCH1 Protein, His-tagged | +Inquiry |
Notch1-1837M | Recombinant Mouse Notch1 Protein, His-tagged | +Inquiry |
NOTCH1-461H | Recombinant Human NOTCH1 Protein (Ala19-Gln526), HIgG1 Fc-tagged | +Inquiry |
◆ Lysates | ||
NOTCH1-469MCL | Recombinant Mouse NOTCH1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionNOTCH1 contributes to the regulation of embryonic development and tissue homeostasis by influencing cell differentiation and proliferation.
The ligands or interacting partners of NOTCH1 include Delta-like 1 (DLL1), Delta-like 3 (DLL3), Delta-like 4 (DLL4), Jagged 1, and Jagged 2, regulating its activation.
Neurogenic locus notch homolog protein 1 (NOTCH1) functions in cellular processes, primarily playing a role in the Notch signaling pathway.
Dysregulation or abnormal expression of NOTCH1 is associated with conditions such as cancer, cardiovascular diseases, and developmental disorders.
NOTCH1 is predominantly localized on the cell membrane, where it undergoes proteolytic cleavage upon activation.
There are potential therapeutic implications related to NOTCH1 in diseases involving Notch signaling, making it a target for drug development.
NOTCH1 participates in the Notch signaling pathway by interacting with ligands such as Delta and Jagged, influencing cell fate determination.
Customer Reviews (3)
Write a reviewContinuous access to up-to-date training materials ensured that our team remained well-versed in the product's capabilities.
The product's evolution in response to user feedback showcased a dedication to meeting the evolving needs of researchers.
The product's compatibility with open science practices positively influenced our decision to adopt it for our experiments.
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