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Recombinant Human COL1A1 Protein, His-tagged

Cat.No. : COL1A1-114H
Product Overview : Recombinant human COL1A1 protein(Gln23-Lys277 + Gly1094-Leu1464) with an N-terminal 6-His tag was expressed in Chinese Hamster Ovary cell line.
  • Specification
  • Gene Information
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Description : This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Source : CHO
Species : Human
Tag : His
Molecular Mass : 65 kDa
N-terminal Sequence Analysis : His & Asp1219
Endotoxin : <1.0 EU per 1 μg of the protein by the LAL method.
Purity : >80%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Gene Name : COL1A1 collagen type I alpha 1 chain [ Homo sapiens (human) ]
Official Symbol : COL1A1
Synonyms : COL1A1; collagen type I alpha 1 chain; OI1; OI2; OI3; OI4; EDSC; EDSARTH1; collagen alpha-1(I) chain; alpha-1 type I collagen; alpha1(I) procollagen; collagen alpha 1 chain type I; collagen alpha-1(I) chain preproprotein; collagen of skin, tendon and bone, alpha-1 chain; collagen, type I, alpha 1; pro-alpha-1 collagen type 1; type I proalpha 1; type I procollagen alpha 1 chain
Gene ID : 1277
mRNA Refseq : NM_000088
Protein Refseq : NP_000079
MIM : 120150
UniProt ID : P02452

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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